UV LEDs are widely used in medical equipment and disinfection of household products. A team in Denmark further found that treatment combined with ultraviolet radiation could help enhance the effectiveness of bacteria in eradicating antibiotics.
Therefore, light adjuvant therapy can reduce the use of antibiotics. Excessive use of antibiotics can lead to bacterial resistance, with the worst-case scenario being an incurable disease. To prevent this, researchers are trying to find alternative therapies to reduce the use of antibiotics. As people become aware of the bactericidal function of UV LEDs, Danish researchers have found that ultraviolet radiation at specific wavelengths in vitro can more effectively eradicate bacteria in the biofilm state than antibiotics.
In addition, according to the team, the combination of UV radiation and antibiotics can better eliminate bacteria, resulting in a new concept of light-assisted antibiotics. In the study, the team used UV LEDs with wavelengths ranging from 249nm to 338nm for radiation therapy to kill bacteria on the iofilm. The results show that the irradiation effect is more significant in the wavelength range of 292~306 nm, and the effect of 296 nm is the best.
The results of the study were published in the scientific report on November 5. By revealing the concept of light-assisted antibiotic methods, the team hopes to help develop new therapies that combine light sources and antibiotics to enhance the treatment of biofilm infections.